According to the National Health Commission’s statement, the protection effect after vaccination with the neo-crown vaccine is not 100%, because there are individual differences, so it is possible to get infected with neo-crown virus after vaccination. At the same time, clinical data now show that there are still cases of neo-coronavirus infection after neo-coronavirus vaccination, but vaccination can greatly reduce the rate of death after neo-coronavirus infection. After vaccination against neo-coronavirus, due to individual variability, it takes longer for some people to produce antibodies, which do not provide protection for a period of time. In addition, if the concentration of antibodies in the body is low, if the immunity is not sufficient, when the new coronavirus invades the body again, it will cause re-infection due to low resistance. At the same time, there is a possibility of mutation of the neo-coronavirus, and when the genetic material of the virus mutates, the vaccine in the body will not be able to effectively resist the mutated strain, thus causing infection. However, according to the clinical data survey, the effectiveness of inactivated vaccine against neostriatal infection in China is 65.9%, the protection against hospitalization rate of patients is 87.5%, the protection against ICU admission rate is 90.3%, and the protection against death is 86.3%. Therefore, although complete immunity may not be achieved after vaccination with the neo-coronavirus, the neo-coronavirus vaccine is effective in reducing patient symptoms and death if infection with the neo-coronavirus occurs. In conclusion, in order to reduce the risk of neo-coronavirus infection, neo-coronavirus vaccination should still be actively administered. At the same time, since the vaccine cannot guarantee 100% protection, it is still important to follow national vaccination measures after vaccination against NCCV, reduce access to crowded places, wear masks when going out, wash hands and ventilate more often in daily life, and seek medical attention in case of uncomfortable symptoms.