Hypertensive nephropathy patients with high blood pressure and leg swelling can take Irbesartan Hydrochlorothiazide, and pay attention to monitoring kidney function and electrolytes. Patients with hypertensive nephropathy will have abnormal renal function, glomerular filtration rate will decrease, you can take oral treatment of Irbesartan Hydrochlorothiazide, lowering blood pressure at the same time have a protective effect on the kidneys, at the same time, can be able to discharge excess water in the body. Irbesartan hydrochlorothiazide belongs to the western prescription drugs, for the compound preparation, including Irbesartan and hydrochlorothiazide, to not have adverse reactions to headache, dizziness, arthralgia, fatigue, weakness, nausea, dry mouth, low blood pressure, electrolyte disorders, etc., allergic to the drug components, late pregnancy and lactating women, severe liver and kidney insufficiency patients are prohibited. When patients with hypertensive nephropathy are taking Irbesartan Hydrochlorothiazide orally, electrolyte and renal function tests should be strengthened, and if the creatinine level rises persistently, the drug should be discontinued and the dosage should be reduced in time and the treatment should be adjusted under the guidance of the physician.