Major and Minor Triple Positive are generally referred to as Hepatitis B Major Triple Positive and Hepatitis B Minor Triple Positive. Hepatitis B major triple positive and Hepatitis B minor triple positive are indicators of the two halves of the Hepatitis B virus. The difference between the two is Hepatitis B E antigen, Hepatitis B E antibody and infectiousness. 1. Hepatitis B E antigen: Triple positive refers to positive surface antigen, positive E antigen and positive core antibody in the five items of Hepatitis B. It means that one, three and five items are positive. The positive E antigen means that the virus is in the active stage, so the infectiousness and viral activity of the major triple positive is stronger than that of the minor triple positive. 2. Hepatitis B E antibody: Hepatitis B minor triple positive generally refers to positive surface antigen, positive E antibody and positive core antibody in Hepatitis B, i.e. one, four and five positive. When the E antibody is positive, it indicates that the patient’s body has developed resistance and certain immunity, so the replication and activity of hepatitis B virus of small triple positive is weaker than that of large triple positive. 3. Infectiousness: Because of the strong viral replication ability of the major triple positive, the infectiousness of the major triple positive is generally stronger than the infectiousness of the minor triple positive. Major and minor triple positive are different immune states of hepatitis B, and have nothing to do with the severity of the disease, the severity of the disease also depends on the patient’s liver function, viral quantification, liver and gallbladder ultrasound and so on. Patients should go to the hospital regularly for follow-up, and under the guidance of the doctor, complete the relevant examinations to clarify the condition and provide systematic and regular treatment.