Plantar warts are a result of the body carrying HPV, but there are more than 100 subtypes of the HPV virus. Plantar warts are caused by human papillomavirus type I (HPV-1) or type IV (HPV-4), and other types have also been reported. Plantar warts are benign growths that grow on the skin of the plantar region of the foot, often on the heel, the front of the plantar region, or on pressure areas between the toes. The condition is characterized by multiple lesions, clusters, or several adjacent warts fused to each other; exfoliation reveals a lax keratinous soft core surrounded by scattered small black dots due to capillary hemorrhage. When the warts are large, the patient has pain when walking, affecting daily life. Some of the plantar warts can disappear on their own, but the pain is more obvious, the lesions are multiple and the large area spreads, need to be treated. The treatment of plantar warts is mainly topical medication (salicylic acid ointment, interferon gel, etc.) and physical therapy (freezing, laser, etc.). Since there is no effective anti-HPV drug, some immunomodulators, such as cimetidine, can be used. It is recommended that patients with severe plantar warts consult a doctor in time and choose the appropriate treatment plan under the guidance of a professional doctor.