(Disclaimer: This article is for general use only, and the information in the following content has been processed to protect patient privacy) Abstract: The patient presented to the hospital with increased vaginal discharge with foul odor and bleeding during intercourse. After gynecological internal examination and biopsy, she was diagnosed with vaginal squamous cell carcinoma, which is a relatively rare type of vaginal malignancy, and was recommended to be hospitalized for surgery. After the surgery, she was treated with adjuvant chemotherapy and radiotherapy. During the follow-up, the patient’s condition was controlled stably and there was no recurrence of the tumor. [Basic information] Female, 58 years old [Disease type] Vaginal squamous cell carcinoma [Hospital] Jinan Hospital of Integrative Medicine [Date of consultation] February 2021 [Treatment plan] Surgery (transabdominal extensive total hysterectomy and upper vaginal resection, pelvic lymph node dissection) + pneumatic therapy + drug therapy (Ornidazole tablets, Ceftriaxone sodium for injection, sodium lactate Ringer injection, tranexamic acid injection) + The patient reported that she had been menopausal for 8 years, and her vaginal discharge decreased significantly after menopause in the previous years, but in the past 2 years, she had increased discharge, sometimes yellowish in color, with foul odor. Recently, she has experienced bleeding during intercourse, often accompanied by abdominal pain and back pain. She had not undergone any systematic examination and treatment before, but her symptoms worsened recently, so she came to our gynecology clinic for consultation. After internal gynecological examination and biopsy of the mass, the pathological diagnosis was vaginal squamous cell carcinoma, and the cervical pre-cancer screening test was positive for HPV18. Treatment After admission, blood and urine routine, blood group, coagulation function, biochemistry, virus complete set, cardiac enzymes, electrocardiogram, chest X-ray and other examinations were completed, and surgical evaluation was performed according to the results. Ceftriaxone sodium for injection was given 3 days before surgery as an IV to prevent infection and vaginal scrubbing for 3 days. There was no significant abnormality in the examination results and there were no obvious contraindications to surgery. Postoperatively, he was given cardiac monitoring, oxygen, continuous catheterization, continuous abdominal drainage, acupressure to help exhaustion, pneumatic therapy to prevent venous thrombosis of both lower limbs, and ornidazole tablets and ceftriaxone sodium for injection in an IV drip to prevent infection, sodium lactate Ringer injection for rehydration, and tranexamic acid injection in an IV drip to prevent postoperative bleeding. After the operation, the drainage bag was removed after the flow was less than 50 ml, and the urinary catheter was removed after the residual urine volume was normalized by intermittent urine opening. After the operation, chemotherapy (paclitaxel injection and carboplatin injection) was given in combination with radiation therapy. The patient recovered well, with good general condition, stable vital signs, no vaginal bleeding and fluid, no abdominal pain and back pain, and light self-reported incision pain. discomfort symptoms. The patient was assessed to be recovering well and given chemotherapy with TP regimen. The blood count was checked in the normal range and the patient had no obvious symptoms and was recommended to be discharged. After discharge, the patient continued chemotherapy for 3 courses and went to the oncology department in combination with radiotherapy. During the follow-up, it was found that the patient’s condition was under stable control and no tumor recurrence. We are glad that the patient’s condition has been improved after treatment, but we still need to remind the patient to pay attention to the following matters in daily life: 1. It is recommended that the patient should take more rest after surgery, do not work too hard, do not do heavy physical labor, and ensure sufficient sleep, which is conducive to postoperative recovery; 2. Avoid eating spicy and stimulating food, cold and blood-activating food; 3, the body’s resistance and immunity decreases after surgery, pay attention to personal hygiene, care for abdominal wounds, avoid wound infection, wash the vulva with warm water every night; 4, 2 months after surgery, sexual intercourse and tub bathing are prohibited, 2 months later, follow-up gynecological clinic, ultrasound or CT can be done to assess the postoperative pelvic recovery, gynecological examination to see the recovery of the vaginal stump, as well as follow-up blood tests, routine blood tests and CT. We can do ultrasound or CT to assess the pelvic recovery after surgery, internal gynecological examination to see the recovery of the vaginal stump, and recheck the blood routine and tumor markers, etc. V. Personal insight Vaginal squamous cell carcinoma is not common in gynecological clinics, and most of the early stage patients have no obvious discomfort symptoms, so they are easily ignored and do not seek timely consultation, examination and treatment, resulting in the aggravation of the disease at a later stage, and the development of advanced stage can no longer be treated surgically, and the survival time of patients will be significantly affected. If symptoms such as vaginal bleeding and bleeding during intercourse occur, patients must go to the hospital in time, and if there are no uncomfortable symptoms, they should also have regular gynecological examination and pre-cervical cancer screening to achieve early detection and treatment. In this case, the patient was found in time and belonged to the early stage of the disease, and the later treatment effect was more satisfactory.