Abstract OBJECTIVE: This paper reviews the experience of performing single-center analytic surgery combined with minimally invasive, a new hybridization technique, for the simultaneous treatment of aortic lesions in the arch and thoracoabdominal segments. METHODS: Five cases of aortic lesions were treated concurrently by applying hybridization technique since June 2007 DD May 2008. One case of thoracic descending aortic aneurysm involving hemiarch combined with coarctation, one case of arch descending aortic aneurysm, one case of Debarkey type III acute aortic coarctation, and two cases of infrarenal abdominal aortic aneurysm involving bilateral common and internal iliac arteries. The proximal anchor zone of the arch was classified as Zone ZAP0 in 2 cases and Zone ZAP2 in 1 case. The arch descending aortic aneurysm was treated with ascending aorta to bilateral common carotid artificial vessel bypass + left common carotid to left subclavian artery bypass with simultaneous release of Zenith overlapping stent via femoral artery under DSA. Debakey type III entrapment was performed with left common carotid to left subclavian artery bypass followed by release of overlapping stent to close the rupture. For abdominal aortic aneurysms involving both internal iliac arteries, the abdominal aortic bifurcation stent was released after prior bypass of the internal and external iliac arteries. RESULTS: The surgery was successfully completed in 5 cases, and no endoleaks occurred on immediate postoperative imaging and follow-up CTA with a follow-up period of 2 months DD10 months. The bleeding volume was between about 200DD600ml, and none of them had blood transfusion. one case of ARDS after arch hybridization followed by pulmonary infection, tracheotomy was performed three weeks after surgery and discharged after symptomatic treatment, acute left heart failure occurred three months after surgery and recovered after controlling blood pressure (lower extremity). one case died suddenly due to cardiac accident while eating three weeks after surgery. The time of each carotid artery block was less than 10 minutes in both cases treated with arch hybridization, and both had no neurological complications or mild neurological symptoms. CONCLUSION: The selection of appropriate different combinations of aortic hybridization modalities is a prerequisite for this group of treatments. In addition to the high cost of treatment, the application of surgery combined with minimally invasive, a new hybridization technique for the treatment of aortic lesions in all thoracoabdominal segments, is beneficial in reducing the hemodynamic alterations caused by surgical trauma and extracorporeal circulation, etc. [Keywords] Aneurysm, coarctation, aortic arch, abdominal, hybridization. Aortic arch and descending aneurysms are extremely risky due to severe neurological complications, and the high complication and mortality rates of traditional arch surgery are a great challenge for surgeons. Hybrid technique is often translated as “composite” technique or “hybrid” technique, and recently it has been applied to large vessel patients in China and abroad. In this paper, we report our initial experience with the hybrid technique in the treatment of aortic lesions.