Progesterone is an important progesterone, a hormone necessary for the maintenance of pregnancy. Low pregnancy progesterone may be caused by fluctuations in progesterone levels in normal physiological state, luteal insufficiency, poor quality of the embryo itself, etc. If luteal insufficiency occurs, it is easy to have preterm abortion and requires fertility preservation treatment. Common causes and treatment 1. fluctuation of hormone level: the detection of progesterone level in serum in early pregnancy shows pulse fluctuation, if the embryo develops well and the blood HCG doubles well, there is no need to worry excessively and no special treatment is needed; 2. insufficient luteal function: the mother’s own ovarian luteal function is insufficient, and it is difficult to secrete enough progesterone during early pregnancy to sustain the continuation of pregnancy, which will easily lead to preterm miscarriage and needs to be given Progesterone supplementation therapy is generally used, and the commonly used ones are progesterone capsules, dydrogesterone tablets and progesterone injection. In the process of fetal preservation treatment, attention should be paid to monitoring the change of progesterone value, and at the same time, attention should be paid to detecting the development of the embryo in the uterus, less activity, more rest and prohibition of intercourse; 3. Poor quality of the embryo itself: due to the abnormal development of chorionic trophoblast, it is difficult to produce enough HCG, so it cannot stimulate the ovaries to produce enough progesterone, and in this case, miscarriage is difficult to avoid, and once inevitable miscarriage occurs, timely In such cases, miscarriage is unavoidable, and once inevitable miscarriage occurs, pregnancy should be terminated promptly. Precautions 1. In life, patients should pay attention to maintaining emotional stability, avoiding mental tension, paying more attention to rest, avoiding strain, strengthening nutrition and paying attention to balanced diet; 2. Before the progesterone test, eat lightly during the day and avoid smoking and alcohol; 3. After the injection of exogenous progesterone in fetal preservation treatment, the body may experience adverse reactions such as nausea, vomiting and breast distension, which are normal physiological conditions.