Case summary: 1. The patient has a history of embryonic abortion and this is her second pregnancy. The patient was particularly nervous about this pregnancy because of her previous history of sterilization, which can be seen from the frequency of her consultations and examinations. In fact, we don’t recommend to check progesterone and HCG as frequently as we do, we recommend to check progesterone and HCG once a week and ultrasound once every 10-14 days. Too frequent tests may make the patient more nervous and even restless. 2. In this case, there was a small amount of vaginal bleeding at 38 days of pregnancy, and the bleeding has been intermittent since then, but it stopped on its own after a while, and no accumulation of blood was seen under the fetal sac. Bleeding in early pregnancy is usually a sign of preterm miscarriage and may indicate damage to the embryo. The bleeding may be caused by the chorionic villi invading the mother’s meconium and injuring the blood vessels, or it may be due to other causes. However, more than half of the patients are still able to continue their pregnancy. Therefore, the bleeding should not be alarming. Progesterone was gradually increased and replenished, and from 7.5 weeks of gestation, progesterone rose steadily and stabilized at more than 30ng. It shows that there is a process of progesterone rise in early pregnancy. Is the rise in progesterone due to progesterone supplementation? There are certain factors. However, in our experience, poor embryos do not achieve the desired level of progesterone despite the use of adequate progesterone. As the embryo develops, the placenta gradually develops, and the progesterone secretion function of the placenta gradually takes over from the corpus luteum, which explains why some pregnant women have low progesterone levels in the early stages and gradually increase them later. Exogenous progesterone supplementation is usually provided until 12 weeks or more, when the placenta has developed to a certain extent and is able to secrete sufficient amount of progesterone, then stop using exogenous progesterone. 4. From the changes of blood HCG in this case, we can see that the highest value of HCG usually appears between 7.5 and 9 weeks of pregnancy, and then there is a slight decrease. The reason for the decrease is that, except for the trophoblast cells at the placenta, the rest of the trophoblast cells gradually degenerate and shrink, and HCG is secreted by the trophoblast of the embryo. 5. This patient had hyperemesis during pregnancy and had a termination of pregnancy at 36 weeks of gestation. Are the factors of hyperemesis associated with first trimester termination? Is it related to early bleeding in the second pregnancy? is an open question.