Shortness of breath in the middle of the night may be heart disease, sleep apnea, cardiac neurosis and so on. 1. Heart disease: may be cardiac insufficiency, angina pectoris and other diseases, the patient may have myocardial ischemia or chronic pulmonary stasis, the condition is aggravated during sleep, the symptoms of chest tightness and shortness of breath can occur. 2. Sleep apnea: it is easy to attack during deep sleep at night, and the patient may have temporary hypoxemia, which may also lead to hypoxia, and the patient may show symptoms of chest tightness and shortness of breath. 3. Cardiac neurosis: patients with mental stress, or excessive tension and anxiety, night sleep can be manifested as chest tightness and shortness of breath, but without the presence of organic disease. In the middle of the night is always chest tightness and shortness of breath of patients, to the hospital in a timely manner to carry out relevant examinations, to clarify the specific diagnosis, under the guidance of the physician to give treatment.