Fungal infections on the hands peeling and cracking can be significantly improved through lifestyle adjustments with medication. 1. Lifestyle adjustment: patients should develop good hygiene habits, avoid scratching other parts of the body with the affected area, so as not to cause cross-infection. Keep the affected area clean and hygienic. 2. Medication: (1) Topical medication: using sodium bicarbonate solution to wash the fingers can avoid the continuous reproduction of fungus and control the infection at the same time. Local application of ointment, such as itraconazole ointment, terbinafine ointment, erythromycin ointment, etc., can eliminate inflammation, and at the same time can relieve itching. (2) Oral medication: If there is no improvement after the above treatment, oral medication is recommended, such as terbinafine, itraconazole and so on. The treatment of fungal infections of the hand may lead to recurrence if the course of treatment is too short, and it is necessary to standardize the use of medication under the guidance of a doctor. The use of drugs need to follow the doctor’s instructions.