Botulinum toxin is a type A toxin secreted by the bacterium Clostridium botulinum, which was isolated in 1895 by Prof. vanErmengen from cured hams that caused food poisoning. Botulinum toxin is able to poison people because it can block the control of nerves to muscles, making the muscles in the affected area unable to move. In the case of food poisoning, the patient’s respiratory muscles are affected by the intake of a large amount of botulinum toxin at once, which can lead to respiratory arrest, but botulinum toxin is not toxic to the body organs, as well as to the nerves and muscles themselves. Li Huawei, Department of Pediatrics, The First Affiliated Hospital of Henan College of Traditional Chinese Medicine Botulinum toxin acts on the peripheral nerve endings, nerve-muscle contact points, i.e., synapses, inhibiting the release of nerve mediator acetylcholine from the presynaptic membrane and thus causing relaxation paralysis of the muscles, and playing a therapeutic role in relieving spasms and ankylosis. Botulinum toxin is mainly injected in the spastic local muscle, rarely spread to the blood, so the systemic side effects are very few. As a result of figuring out the mechanism of action of botulinum toxin, the attitude of doctors towards botulinum toxin has changed significantly, from the early fear and loathing, to now find ways to utilize it for the treatment of human diseases. Clinically, Botox has been used by neurologists to treat a variety of spasticity, tonus, and tremor disorders. Botulinum toxin is very safe as the dose used for treatment is only 1% of the toxic dose.