I. Introduction of chromosomal abnormalities Generally, chromosomes need to be checked in two cases: the male partner’s repeated semen routine examination concentration are less than 10 million/mL; those with a history of two (including two) or more spontaneous abortions, especially early abortions (within 3 months of pregnancy). In the course of pregnancy, about 7% of spontaneous abortions occur, which can be considered as eugenics; however, of the repeated abortions (those with a history of two (including two) or more spontaneous abortions, especially early abortions (within 3 months of pregnancy)), further tests are needed to clarify the cause of abortion: about 50% of them are abnormal fetal chromosomes, the rest may be related to the female partner’s intrauterine environment, and some are limited to the existing medical The rest may be related to the intrauterine environment of the woman, and some are of unknown origin due to the current medical level. The incidence of chromosomal karyotype abnormalities in patients with azoospermia is 10-15%, in patients with oligospermia is 4-5%, and in patients with normal or basically normal semen parameters is 1%. Second, clinical management of patients with interarm inversion Big Y refers to chromosome greater than or equal to chromosome 18. Big Y is a normal variant, but it cannot be said to be absolutely normal. It is best to consult with a geneticist or a reproductive gynecologist’s.