Drug crystals blocking renal tubules will appear oliguria and anuria, hematuria and proteinuria, hypoproteinemia and other symptoms, drug crystals blocking renal tubules will appear drug-induced kidney injury. 1. Oliguria and anuria: most of them are sulfonamides and methotrexate, etc. Their crystals blocking the renal tubules will cause obstructive renal damage, resulting in oliguria and even anuria symptoms. 2. Hematuria and proteinuria: If the drug is nephrotoxic drugs, such as cephalosporins, these drugs have a direct toxic effect on the kidneys, resulting in hematuria and proteinuria. 3. Hypoproteinemia: mostly seen in non-steroidal anti-inflammatory drugs, such as ibuprofen, etc., this kind of drug will lead to the emergence of nephrotic syndrome, mainly manifested as hypoproteinemia, edema and so on. If you have similar symptoms after taking the drug, it is recommended to consult a doctor in a timely manner, under the guidance of a professional doctor to improve the examination, to clarify the cause of the disease, so as to avoid delaying the condition.