Prothrombin activity mainly reflects the activity of coagulation factors and is used to determine whether the coagulation function and reserve function of the liver are intact and related to the severity of the patient’s condition. The normal range of prothrombin activity is 75%-100%. When prothrombin activity is high, it is often due to exogenous coagulation dysfunction. In this case, the cause of high prothrombin activity needs to be identified and treatment given for the cause. The common clinical causes of high prothrombin activity are the following: 1, vitamin K deficiency: mainly due to vitamin K deficiency causing coagulation dysfunction in the body, and then the patient can appear high prothrombin activity, manifested as skin mucosal bleeding, petechiae and other symptoms. Daily, you can eat foods rich in vitamin K, such as spinach, cilantro, cauliflower, kale and so on. Also for milder symptoms, vitamin K1 can be taken orally under the guidance of a doctor. If the symptoms are more severe, vitamin K1 can be infused intravenously. If necessary, coagulation factors can be supplemented and frozen plasma can be infused for treatment under the guidance of a doctor; 2. Diffuse intravascular coagulation: usually due to infection, disease and other factors leading to the activation of the systemic intravascular coagulation system, which can be manifested as high prothrombin activity, and patients can show clinical symptoms such as bleeding, shock and organ damage. Treatment can be substituted by giving blood products such as fresh frozen plasma, fresh whole blood, and concentrated platelet suspensions under the guidance of a physician. For patients with chronic diffuse intravascular coagulation, heparin can be applied for treatment as prescribed by the doctor; 3. Other: For example, high prothrombin activity may also occur in women who take birth control pills frequently, have hyperlipidemia, or have thrombotic or hemolytic diseases. In addition, high prothrombin activity may also occur if the blood specimen is shaken vigorously during or after the blood draw. Patients are advised to promptly identify the cause and provide symptomatic treatment to address the etiology. It is also important to avoid vigorous shaking during the collection of blood specimens or during the sending of blood specimens for testing to avoid false positives. In addition, it is important to note that low prothrombin activity may be caused by liver disease, such as hepatitis, cirrhosis, or liver failure. If prothrombin activity is <40% in patients with acute hepatitis, it is often a precursor to fulminant hepatitis with massive hepatocyte necrosis.