1.How is the genetic test for ALS performed? How long does it take to get the results? Genetic testing for patients is a test tube of blood sent to the laboratory, which compares and analyzes the genes through various means and finally produces the results. Nowadays, genetic testing technology is roughly divided into first-generation sequencing and second-generation sequencing. First-generation sequencing is to extract DNA for amplification, and after amplification, sequencing is performed; second-generation sequencing is to build a sequencing platform with larger capacity, mark out the genetic loci with possible variants, and then compare them with the patient’s related genes to detect whether the patient has problems with these genes. First-generation sequencing generally produces results in about a month; second-generation sequencing is relatively more complex, but the detection technology is more advanced, and it generally takes a month to two months to produce results. 2. Is it up to the patient to choose which sequencing technology to use? It is not the patient’s choice, in a sense it is not the doctor’s choice either, it is the testing organization or the institute that sets it up according to their own manpower and technical cost. Of course, in theory, the newer the sequencing, the better, but the more advanced the technology, the higher the cost of testing. 3.Will there be any difference between the two sequencing technologies in terms of results? There is almost no difference, no matter which technology is used, the result is actually to see if the gene is mutated, the final observation is the same, the two technologies are only different detection means. 4.What institutions or departments can perform genetic testing? Now there are two types of genetic testing institutions, one is called a clinical diagnostic testing institution, and one is a research and testing institute. Clinical testing: can be done in large hospitals or clinical testing institutions, mainly for clinical diagnosis, and this type of testing needs to be charged according to clinical standards; scientific research testing: is a certain amount of blood retained by the doctor from the patient voluntarily, on the one hand, for scientific research, on the other hand, when there is a positive result or a meaningful result for the patient to provide the patient for reference, this kind of testing is free. In some cases, the doctor will ask the patient if he or she wants to have a fee-based test or a non-fee-based test. A fee-based test means that the test provider will give the results of the test within a certain period of time, whether they are positive or negative; a non-fee-based test is used for scientific research, so there is no routine procedure to guarantee when the results will be available, which results will be available, and which results will not be available for a while. These two types of tests are not the same. 5.Will patients be notified of the results of the research-based tests? The patient will be informed when there is a positive result or a clear meaning when the blood is left in the hospital, because such a result is meaningful for the eugenics of the patient. If the patient is not informed of the results, then the results may not be meaningful to the patient.