The causes of creatine kinase CPK increase, but also the basis of clinical diagnosis: 1, all types of myotonic dystrophy can occur CPK vitality is elevated, including pseudohypertrophy large myotonic dystrophy enzyme vitality up to about 10 – 50 times the normal. 2, muscle trauma can make CPK vitality increase. 3, strenuous exercise, surgery, intramuscular injection can also cause this enzyme activity to increase. 4, cerebrovascular accident, meningitis, hypothyroidism, etc. can also increase CPK activity. 5. In acute viral or rheumatic myocarditis, CPK activity can be up to 5 times higher than normal. 6.In acute myocardial infarction, the positive detection rate is high and specific in the early stage (2-4H can be increased, 2-4D can be recovered), and the degree of increase in enzyme activity is consistent with the severity of the disease. Creatine kinase is also known as creatine phosphokinase. Under normal conditions, the majority of creatine kinase is located within the muscle cells, and elevated creatine kinase in the blood generally indicates that muscle damage has occurred or is occurring. Chronic elevations of creatine kinase are called hypercreatine kinaseemia and are occasionally seen in normal individuals. 1980 Rowland referred to conditions without clinical and histopathological evidence of neuromuscular disease as idiopathic hypercreatine kinaseemia. In cases of hypercreatine kinaseemia with clinical signs of neuromuscular disease, it is usually possible to make a definitive diagnosis after consultation with a variety of relevant tests. Asymptomatic hypercreatine kinaseemia is defined as follows 1. incidental finding of elevated serum creatine kinase; 2. persistent hypercreatine kinaseemia for at least 3 months; 3. no symptoms or only mild and nonspecific symptoms (occasional mild muscle pain) at the time of presentation; 4. no family history of neuromuscular disease; 5. lack of clinical manifestations of neuromuscular disease associated with hypercreatine kinaseemia; 6. no cardiac disease (CK-MB and ECG normal); 7. No other causes of hypercreatine kinaseemia (malignancy, alcohol and drug abuse, systemic metabolic diseases, infections, malignant hyperthermia, thyroid and parathyroid disorders, hematologic disorders, pregnancy, drugs, etc.). For those who are determined to have asymptomatic hypercreatine kinaseemia, the following tests should generally be performed to clarify the cause. 1. neurological systemic examination, especially muscle strength. 2. creatine kinase assay by family members. 3. blood lactate test: including basal state, after forearm ischemia, and after exercise. 4. needle electrode electromyography. 5. muscle biopsy, specimens for routine histology, multiple histochemical staining, immunohistochemical staining for certain antibodies, and electron microscopy. If the results are still negative after the above mentioned systems, idiopathic hypercreatine kinaseemia can be considered.