There are no medications that treat rheumatoid arthritis with minimal side effects; all medications have side effects that vary from person to person. Commonly used drugs for rheumatoid arthritis include non-steroidal anti-inflammatory drugs (NSAIDs), immunosuppressants, and botanical preparations. 1. Non-steroidal anti-inflammatory drugs (NSAIDs): they have analgesic and anti-inflammatory effects and can relieve joint inflammation, such as ibuprofen and meloxicam, etc. Side effects are mainly gastrointestinal reactions. 2. Immunosuppressants: common as methotrexate, it is the first choice of drugs for the treatment of rheumatoid arthritis and the basic drugs for the combination of drugs, common side effects include liver function damage, gastrointestinal reaction, bone marrow suppression, etc., need to be regularly tested for liver and kidney function, blood routine. 3. Phytopharmaceutical preparations: common such as tretinoin, white peony total glycosides, etc., can relieve the pain symptoms of joints, adverse effects include gonadal suppression, bone marrow suppression, liver damage, and so on. Any drug has certain side effects, and the specific medication needs to be selected according to their own situation, so it is recommended that patients with rheumatoid arthritis, timely to the rheumatology and immunology department of the regular hospital, regular use of medication under the guidance of the doctor, regular checkups, and avoid self-medication to avoid delays in the condition or adverse reactions.