Premenstrual disorders in 49-year-old women may be caused by the decline of ovarian function and unstable changes in hormone levels, and are common symptoms of the menopausal transition, usually manifested in irregular menstrual cycles and changes in the period and volume of menstruation. 1. Menstrual cycle: the menstrual cycle is irregular and can be extended to several months or shortened to ten days, and there is even no obvious cycle interval; 2. Period and volume: the period lasts for a long time and can There are also changes in the volume of menstruation, and even anemia due to excessive bleeding, until the ovaries fail and menstruation stops. In addition, in addition to menstrual disorders, premenopause can also show symptoms such as hot flashes, agitation and irritability, anxiety and suspicion, depressed mood, lowered self-confidence, loss of emotional control, and often memory loss and lack of concentration and sleep disorders. Women can use progestin medication under the guidance of a doctor, which can effectively improve the abnormal menstruation phenomenon caused by premenopause, and the specific dosage and duration of medication should follow the doctor’s prescription.