Most medication edema resolves in about three days after stopping the medication, but it may deviate depending on the individual’s constitution. There are many primary drugs for drug-induced edema, such as calcium channel blockers like nifedipine and hormonal drugs like dexamethasone, and the typical clinical symptom is edema of the lower limbs, especially the ankles. This drug-induced edema can be relieved after stopping the drug, mild cases of edema can subside on the same day of stopping the drug, most of them will be eliminated in about three days after stopping the drug, and the serious ones may need a week to be relieved. The specific time for the swelling to subside is related to the individual’s physical condition and the residual concentration of the drug in the body. Patients should follow the doctor’s instructions to stop or reduce the amount of medication, do not stop the drug without authorization because of edema, should be adjusted according to the doctor’s recommendations. During the edema period, pay attention to light diet, eat less stimulating food. All drugs should be used in accordance with medical advice.