What is the effect of ovarian perforation on ovarian reserve function in patients with PCOS?

The preferred method of ovulation promotion in infertile patients with polycystic ovary syndrome (PCOS) is the use of clomiphene (CC), however, surgery is an effective treatment for clomiphene-resistant PCOS patients. Ovarian wedge resection has been used in the treatment of PCOS since 1935, but it has been largely replaced by laparoscopic ovarian perforation (LOD) due to side effects such as surgical trauma and postoperative pelvic adhesions. The results of LOD for PCOS patients are well recognized, with reported ovulation rates as high as 80%-90% and pregnancy rates of 40%-60%. LOD also has other advantages, such as being effective in reducing the incidence of ovarian hyperstimulation syndrome (OHSS) and multiple pregnancies. Therefore, LOD is currently considered as a second-line treatment for patients with PCOS infertility. However, since Dabirashra fi et al. reported a case of LOD resulting in severe impairment of ovarian function, the effect of LOD on ovarian function has gradually gained attention. After laparoscopic bilateral ovarian perforation, ovarian reserve function is slightly reduced in patients with PCOS, but it does not usually lead to the development of POF. Due to the presence of excessive ovarian reserve function in PCOS patients themselves, patients still have higher than normal ovarian reserve function even after LOD. In order to avoid ovarian reserve function impairment, attention should be paid to protect ovarian function in LOD by minimizing the perforation power, reducing the number of perforations and shortening the perforation time on the basis of ensuring the therapeutic effect, and considering the use of techniques that are less destructive to ovarian tissues, and the long-term effects of LOD on the ovarian reserve function of patients need to be further studied.