The dangers of psoriasis, or psoriasis, with the use of biologics include injection site reactions, infections, and allergic reactions. Psoriasis is a skin disease caused by multifactorial interactions, and is mainly characterized by scaly erythematous patches or plaques of the skin, which may be confined to one place or widely distributed throughout the body. Biologics, or targeted immunomodulators, are used to treat immune-mediated inflammatory diseases and tumors. They can be used in the treatment of psoriasis and mainly include etanercept, infliximab, adalimumab and tofacitinib. All the use of biological agents should be carried out under the guidance of medical professionals, and their common adverse reactions include injection site reactions (such as pain, swelling, itching, erythema, etc.), infections (such as upper respiratory tract infections, bronchial infections, skin infections, etc.), anaphylactic reactions, itching, fever, etc. The use of biological agents is prohibited for those who are allergic to biological agents and those who are septicemia.