Mycoplasma is the smallest pathogenic microorganism between bacteria and viruses that can live independently on cell-free medium. Clinical symptoms of Mycoplasma infection vary in severity, most of them start not very urgently, with chills and fever, anorexia, cough, headache, sore throat, chest pain and other symptoms, cough is the most important clinical manifestation, and the natural course of the disease varies from a few days to 2~4 weeks. Fever caused by mycoplasma infection may be persistent, or only low fever, or even no fever. In most coughs, the initial irritating, spasmodic dry cough is dominant, followed by coughing up a small amount of mucous sputum, sometimes with blood in the sputum. Mycoplasma infection can shorten the course of the disease after active treatment, preferred macrolide antibiotics, such as erythromycin, azithromycin, etc., but also according to the accompanying symptoms of the symptomatic treatment, cough severe, even wheezing children can use nebulizer treatment, or oral aminobromine oral solution. Traditional Chinese medicine and external therapies also play an important role in alleviating cough symptoms, reducing the duration of fever, and promoting the recovery of rales. During the period of illness, it is necessary to pay attention to rest, drink more water, keep the indoor air fresh, take a light and easy to digest diet, eat more fresh vegetables and fruits, do not eat spicy and stimulating food, usually pay attention to exercise, enhance their ability to resist disease, according to the seasonal increase or decrease in clothing at any time, to prevent catching cold.