Periodontitis is an inflammation caused mainly by bacterial infection, and the main symptom is the swelling and pain of the tooth bed, etc. The treatment of this type of disease is mainly through professional treatment by a dentist, and some patients with severe periodontal inflammation can be treated with antibiotics during oral treatment. The root cause of periodontitis is the accumulation of bacteria in the mouth through plaque and calculus, which destroys periodontal tissues and causes bleeding, swelling and pain in the gums, and even loosening of teeth, so good treatment cannot be achieved by simply using medication without removing the calculus. The mildest cases of periodontitis only require scaling treatment at the dentist to completely remove the calculus and improve periodontal health; more pronounced cases of periodontitis, where the calculus is deep and firmly attached to the tooth roots, require further periodontal scaling to remove the deeper calculus. The damage to the alveolar bone and gums caused by periodontitis is irreversible and must be treated as early as possible to obtain long-term benefits. Some patients with severe periodontal inflammation can be treated with antibiotics during oral therapy, commonly metronidazole, roxithromycin, amoxicillin and other antibiotics, which are selected based on the specific periodontal condition and the patient’s drug allergy. The choice of drugs must be used under the guidance of a doctor, and attention should be paid to avoid the selection of allergy drugs.