Prednisolone is a synthetic hormone that can improve capillary permeability, inhibit inflammatory response, and reduce the damage of pathogenic factors to the body. Procaine hydrochloride is a local anesthetic, which can relieve pain and enhance the efficacy of treatment. Different drugs can play different therapeutic roles. For example, for acute conditions with severe pain, anti-inflammatory and analgesic drugs such as prednisolone and lidocaine can be given to eliminate local inflammatory edema, promote inflammation absorption, and relieve muscle spasm. For chronic lesions with adhesions, drugs that activate blood circulation, resolve blood stasis and relieve pain can be used to eliminate adhesions, soften and disperse knots, remove blood stasis and create new ones, improve tissue metabolism and relieve pain in a variety of ways. Some people worry that the hormonal drugs selected will cause side effects on the human body, in fact, because the closed treatment with a small amount of drugs, will not bring any impact on the human body. Therefore, closed therapy has the advantages of direct drug delivery and rapid therapeutic effect. Some diseases can be cured by closed treatment. Closed treatment should pay attention to the aseptic operation, accurate injection site, the appropriate choice of drugs and other issues. Once the seal therapy is selected, the treatment should also be adhered to, to complete the treatment course, so as not to stop in the middle of the process, not to achieve the desired curative effect. From the point of view of the mechanism of action, closed treatment of chronic pain symptoms such as neck, shoulder, waist and leg belongs to symptomatic treatment. Medical use of this treatment method there are many, antipyretic, antihypertensive, diuretic and so on are, although these methods can not fundamentally remove the cause of the disease, but can play a role in reducing or even eliminating symptoms and preventing complications. Many neck, shoulder, back and leg pain after one or several closed treatment, the symptoms completely disappeared and no longer recur. Therefore, it can not be absolutely believed that closed treatment can not remove the root cause of the disease.