Drug closure therapy is what we often call playing closure, for acute or chronic soft tissue injury, non-purulent inflammation, such as lumbar muscle strain, frozen shoulder, tenosynovitis, myofasciitis, etc.. Commonly used drugs are procaine plus prednisolone acetate or hydrocortisone acetate for local painful spot injection. It should be noted that ① cortisone acetate should never be used for local closure, because cortisone acetate has no local effect and systemic reactions can occur after absorption of the drug, so the drug should be carefully checked before closure. ② prednisolone acetate for local closure, the dosage should not be too large, the interval time can not be too short, the general dose of 12.5 ~ 2.5 mg per time, every 5 ~ 7 days closed once, 3 ~ 4 times for a course of treatment, up to two courses, otherwise the drug accumulates in the local, inhibit the formation of fibrous tissue, so that the local tissue fragile. ③After closed injection, local swelling and pain can appear due to drug reaction, which can be relieved and disappear after 48 hours in general. If there is still redness, swelling and fever after 72 hours, whether there is acute purulent infection should be considered. Like other drugs, hormones are not the legendary “panacea”. For those patients who are not well treated with hormonal drugs, they can be treated with other methods (such as traction, massage, physiotherapy, lumbar brace, internal and external medication, etc.) and, if necessary, with surgery. It should be noted that certain medical units or individual doctors with improper medical style, in the general closed needle plus some other drugs, such as vitamin B injection, angelica injection, or the use of uncommon synonyms, claiming that it is a “secret formula”, “special drugs”, “imported drugs” or “imported drugs”. “imported drugs” or “patented”, the price of drugs will rise by more than ten times or even dozens of times. And in order to make high profits, they induce patients to repeatedly receive treatment in a short period of time, resulting in undesirable side effects.