The antihypertensive drugs used in uremia include β-blockers, calcium channel blockers, α1-blockers, etc. β-blockers can inhibit myocardial contraction and slow down the heart rate to achieve the effect of antihypertensive. 1. β-blockers can inhibit myocardial contraction, slow down the heart rate, to achieve antihypertensive effect, commonly used drugs include metoprolol, bisoprolol, etc., uremia combined with acute heart failure, atrioventricular conduction block patients, can not be used. Adverse reactions include allergy, gastrointestinal reaction, shortness of breath and so on. 2. Calcium channel blocker is to reduce the extracellular calcium ions into the vascular smooth muscle cells, attenuate the contractile effect, reduce the vasoconstrictor response, common drugs include nifedipine, amlodipine, etc., may cause increased heart rate, lower limb edema and other adverse reactions. 3. α1 receptor blockers are common, such as terazosin, can cause peripheral vascular relaxation, adverse reactions include fatigue, palpitations (rapid heartbeat, often accompanied by panic), nausea, drowsiness and so on. In addition, the use of antihypertensive drugs such as angiotensin-converting enzyme inhibitors is not recommended for uremic patients due to abnormal renal function in some non-dialysis patients. When blood pressure rises in uremic patients, it is recommended to consult the hospital in time and choose antihypertensive drugs under the guidance of the doctor, avoid self-medication.