The differential diagnosis of oral acromegaly can be made from the patient’s sexual life history, symptomatic manifestation, pathological examination, dermatoscopic examination and so on. 1. The patient’s sexual life history: oral acromegaly is mostly caused by oral sex infection. The oral acromegaly has a history of bad or inappropriate sexual life, which needs to be considered comprehensively. 2. Symptoms: Oral acromegaly can be manifested as a single or multiple nodules on the lips, back of the tongue, gums and other parts of the body, pale or flesh-colored papillae, cauliflower-like superfluous organisms. And there is no lymph node metastasis in this disease. 3. Pathological examination: it is an important basis for clinical diagnosis of oral acromegaly. If you have oral acromegaly, you can often see the characteristic vacuolated cells of HPV infection. 4. dermatoscopy: often seen in the acetic acid white test and other positive, can be used to clarify the tiny oral acromegaly. If you have a similar oral acne lesion, you should go to the hospital in time, and carry out the hospital related examination, in order to clarify the cause of the disease, and actively cooperate with the doctor’s treatment.