Patients with periungual warts can be treated with ointments such as salicylic acid, fluorouracil and imiquimod under medical supervision. 1. Salicylic acid ointment: mainly can play the role of keratolytic, adverse reactions include local skin irritation. The drug can also be combined with liquid nitrogen cryotherapy for better results. 2. Fluorouracil ointment: it needs to be applied locally daily and sealed locally for 4~12 weeks. The drug has anti-tumor and anti-metabolism effects, can inhibit DNA and RNA synthesis, and can also inhibit tumor proliferation. Some patients may have adverse reactions such as nausea, vomiting and loss of appetite after use, and some patients may also manifest oral ulcers and abdominal discomfort. 3. imiquimod ointment: clinical mainly used for the treatment of anogenital warts, but non-anogenital skin warts also have a certain efficacy. After using the drug may appear erythema, edema, flaking, burning, pain and other adverse reactions. It is recommended that patients with perianal warts be treated with medication strictly under the guidance of a doctor, and that they consult a doctor in a timely manner and follow the doctor’s instructions.