Urea E cream is not able to get rid of wrinkles. Wrinkles are mainly due to local muscle contraction, subcutaneous tissue atrophy and skin laxity, and urea E cream has a moisturizing effect, local use can make the skin smooth, moist, but also can remove the stratum corneum, and not supplement the role of collagen and active substances, so, urea E cream is not able to get rid of wrinkles. Wrinkles clinical generally use injection of botulinum toxin, hyaluronic acid or autologous fat filler, chemical peeling, laser skin rejuvenation, facial abrasion and microdermabrasion and other methods of improvement, patients who have the will to treat can go to the regular hospital dermatology or plastic surgery department for consultation by a professional doctor according to the wrinkles produced by the site to decide the specific treatment method.