Fever in children with mycoplasma infection means that the cause of fever is due to mycoplasma infection. Most fevers are caused by pathogenic infections, which are classified as bacteria, viruses, and Mycoplasma pneumoniae. In addition to bacteria and viruses that cause fever in children, mycoplasma infection is another important pathogen that causes fever in children, especially during the school age when the chance of mycoplasma infection increases. Children with mycoplasma infections may have fever, cough, or even significant shortness of breath, and the diagnosis can be confirmed by testing the child’s blood for antibodies to Mycoplasma pneumoniae. If the blood is positive for Mycoplasma pneumoniae IgM antibodies, the diagnosis of fever due to mycoplasma infection can be confirmed and the child can be treated with erythromycin and other medications.