There is no single drug that can make premature ejaculation effective immediately, and it needs to be tailored to the different causes of the disease in order to play a good therapeutic effect. There are usually three major causes: psychological factors, endocrine disorders and prostatitis. The drugs used include lidocaine, dapoxetine, terazosin and so on. 1. Psychological factors: Psychological factors that cause premature ejaculation include anxiety and depression. The first thing is to relax and exercise in moderation, and the second thing can be treated by behavioral therapy, such as squeezing method and functional-sexual therapy. 2. Endocrine disorders: elevated levels of thyroid-stimulating hormone, thyroid hormone and testosterone in the body may also cause premature ejaculation, and local topical anesthetics such as lidocaine may be chosen to reduce the sensitivity of the head of the penis in order to alleviate premature ejaculation. 3. Prostatitis: the local inflammation caused by prostatitis has a high probability of causing premature ejaculation, you can choose to use dapoxetine combined with alpha-blockers such as terazosin to improve the symptoms of premature ejaculation. The above are just three treatments based on some of the causes, for professional advice, it is recommended to go to the urology department of the hospital as soon as possible for examination and consultation with a doctor.