There is no such thing as the best medication for chronic sinusitis. Chronic sinusitis, with different causes, is treated with different medications. Depending on the specific condition, it can be treated with antibiotics such as clarithromycin and roxithromycin, as well as antihistamines such as ebastine and cetirizine and glucocorticoid drugs such as budesonide. All of the above drugs need to be used under the guidance of a doctor. 1. Antibiotics: The mucosal surface of sinus in chronic sinusitis patients is often covered with bacterial biofilm, and it is recommended to apply macrolide antibiotics, such as clarithromycin. 2. Anti-allergic: patients with allergic rhinitis and asthma need to be treated with certain anti-allergic drugs, including leukotriene receptor antagonists, antihistamines and other drugs, such as montelukast sodium, cetirizine and so on. 3. Glucocorticoid: the treatment of chronic sinusitis can also be applied to glucocorticoid drugs, generally common in clinical practice, such as budesonide, mometasone furoate. Chronic sinusitis, it is not recommended to self-medication, should be timely consultation, follow the doctor’s instructions standardized treatment.