Minor triple sun becomes major triple sun, it is possible that the virus replication is active. The transformation of minor triple positive into major triple positive may be due to the body’s immunity decreasing, or without effective and active treatment, the virus replication is in the active stage or the number of viruses is significantly increased, and at this time, it will be transformed into major triple positive. The transformation of minor triple positive into major triple positive may indicate an aggravation of the disease, and it is recommended to further check the liver function, the number of hepatitis B virus, and liver ultrasound. It is recommended to check the liver function, the number of hepatitis B viruses and liver ultrasound to comprehensively assess whether active antiviral treatment is needed. Hepatitis B patients should consult the hepatology department regularly, develop good living habits, do not drink alcohol, do not stay up late, and review the relevant indicators regularly.