Cephalosporins are a class of antibiotics that are widely used in clinical practice, but with the widespread use of these drugs, many adverse reactions are not known and have to be prevented. If you drink alcohol during the use of cephalosporins, you will have a “double sobriety-like reaction”. The reaction is also called “double sulphur-like reaction”, which is characterized by facial flushing, abdominal pain, nausea, vomiting, headache, dizziness, drowsiness, chest tightness, palpitations, blurred vision and other reactions, and even serious symptoms such as drop in blood pressure, respiratory difficulty, blurred consciousness and shock. The main component of alcohol is ethanol, which is metabolized by oxidation in the body to produce acetaldehyde, which needs to be further metabolized by enzymes in the liver cells to eventually produce carbon dioxide and water. Some drugs inhibit the activity of the above metabolizing enzymes, so that acetaldehyde cannot be metabolized normally and accumulates in the body, resulting in acetaldehyde poisoning and a series of poisoning symptoms mentioned above. The onset of the disease can occur 5 to 10 minutes after the drug user drinks alcohol, and the duration of the reaction can last from 30 minutes to several hours. The severity of the reaction is proportional to the amount of the drug and the amount of alcohol consumed, and the reaction is more serious if the person does not drink alcohol or has a very small amount of alcohol. Reactions after intravenous administration can be more rapid and severe than with oral administration. Therefore, in order to avoid the occurrence of disulfiram-like reactions, alcohol should be avoided during the use of cephalosporins and within one week of stopping the drug. In addition to not drinking alcohol, you should also avoid taking drugs containing ethanol (such as patchouli, nourishing and clearing syrup, etc.), foods (such as flavoring agents, fermented vinegar, wine heart chocolate, etc.) and supplements (such as ginseng and royal jelly). In addition, drugs that can cause such reactions, in addition to cephalosporin antibiotics, metronidazole, dysentery, and biguanide and sulfonylurea hypoglycemic drugs, etc., should not be drunk after use.