Trigeminal neuralgia is a paroxysmal, recurrent, severe pain in the trigeminal nerve distribution area, which occurs in middle-aged women, mostly unilaterally. The nature of the pain is a short-lived electric shock-like, knife-like or tearing pain, with sudden onset and stop, and each attack lasts for a few seconds or tens of seconds, usually less than two minutes. The pain is most pronounced in the cheeks, upper and lower jaws and tongue. There are trigger points, and light touch on the nose, cheek and tongue can induce pain. It can also be induced when washing the face, brushing the teeth, chewing, yawning and talking. So much so that patients are afraid to wash their faces and eat, and show emaciated and depressed faces. Trigeminal neuralgia attacks are frequent, and in severe cases, painful facial convulsions may occur. A condition similar to trigeminal neuralgia is migraine, which is a recurrent throbbing headache on one or both sides. More than 2/3 of migraine sufferers are women, and most have a family history of migraine, with the frequency of attacks varying from once a week to several times a year, with occasional cases of persistent attacks. A typical migraine can be divided into three phases: the aura phase, the headache phase, and the late headache phase. The most common aura is visual aura, such as visual field loss, dark spot, flashing light, etc. 10% of patients have visual aura or other aura, and the aura lasts for several minutes to an hour before entering the headache phase. Most headache attacks last from 2 hours to 1 day. After the headache subsides, there is often fatigue, lethargy, weakness and poor appetite, etc., which can improve in 1-2 days. Reminder: Patients must distinguish what kind of disease they are suffering from, so as to avoid the phenomenon of wrong treatment, which will lead to other diseases. For the treatment of trigeminal neuralgia, it should be subdivided according to the patient’s etiology, condition, age and other factors, and then a personalized treatment plan should be formulated. First, a comprehensive and detailed examination should be performed to confirm whether the condition is primary or secondary. If it is secondary, the exact cause should be found out, and if it is caused by tumor, the tumor should be removed surgically, and if it is inflammatory, it should be treated with anti-inflammatory and pain relief. We wish all trigeminal neuralgia patients to be free from pain and enjoy a pain-free life soon!