1.What are the oral anti-rheumatic drugs commonly used in psoriatic arthritis? (1) Non-steroidal anti-inflammatory drugs (NSAIDs) are suitable for mild to moderately active arthritis, with anti-inflammatory, analgesic, antipyretic and anti-swelling effects, but they are not effective for skin lesions and joint destruction. (2) Slow-acting anti-rheumatic drugs (DMARDs) prevent the deterioration of the disease and delay the destruction of joint tissues. (1) Methotrexate; (2) Salicyclovir; (3) Penicillamine; (4) Azathioprine; (5) Cyclosporine; (6) Leflunomide. (3) Glucocorticosteroids are used for those with severe disease and cannot be controlled by general drug therapy. Because of the many adverse reactions, sudden discontinuation may induce serious types of psoriasis and disease recurrence, so it is generally not suitable for use, and should not be used for a long time. However, some scholars believe that small doses of glucocorticoids can relieve patients’ symptoms and can be used as a “bridge” before DMARDs take effect. (4) Botanical preparations (Radix Rehmanniae) 2. If the disease keeps recurring after taking the drug and the joints are still swollen and painful, should I change the drug or increase the dosage? Recurring disease and swollen and painful joints indicate that the disease is not fully controlled. It is necessary to adjust the dosage and variety of drugs according to the condition and laboratory test results. 3.I am worried about the liver damage of immunosuppressants, how to monitor and protect? Can patients with poor liver function be used? Regularly check the liver and kidney function, and if you find that the liver and kidney function indicators are elevated, you should seek medical advice. Whether to continue to take drugs depends on how high the indicators are. Mild elevation can be continued with medication along with liver protection drugs. Do not decide on your own, but go to the outpatient clinic to see the doctor. 4.Is the use of immunosuppressive drugs prone to infection? How to protect? If applied under the guidance of a doctor, it is generally less likely to cause infection, but if fever occurs, you should go to the clinic in time. 5.How should I treat my leukocytes below 4.0 after using the drug? Should I use white-raising drugs or stop using immunosuppressive drugs? The decision of whether to discontinue the medication depends on the condition and laboratory tests. You can take leukocyte-raising drugs. 6.After taking immunosuppressant drugs, can I change the medication because of severe gastrointestinal reaction? Or should I use drugs to improve gastrointestinal function? If the gastrointestinal reaction is particularly serious, you should stop taking immunosuppressants and switch to other drugs. 7.Does the immunosuppressant need to be used for life, or can it be stopped when the condition improves? The duration of taking immunosuppressants and whether to stop them need to be decided according to the condition and laboratory test results. Regular review and consultation with the Department of Rheumatology and Immunology. 8.When the blood sedimentation, CRP, liver and kidney function and other indicators reach what level can stop the drug? Blood sedimentation, CRP, liver and kidney function and other indicators should be maintained for a period of time after normalization, and when to stop the drug should be decided according to the condition. Do not stop the medication at your own discretion. 9.Do I need to reduce the dosage before stopping the medication and what problems may occur if I stop the medication rashly? Some drugs should be gradually increased. Suddenly stopping the medication may cause relapse.