Chest tightness with something blocking may be due to non-disease causes such as insufficient oxygen in the air, or disease causes such as circulatory, respiratory and mental illnesses. 1. Non-disease causes: When there is insufficient oxygen in the air, it can lead to insufficient oxygen content in the body, affecting normal blood circulation and lung function, which can lead to the symptom of chest tightness and feeling that something is blocking the chest. 2. Disease causes: such as pulmonary hypertension and other circulatory system diseases, may affect its lung function, chest tightness symptoms; when chronic obstructive pulmonary disease and other respiratory diseases attack, its lung function will also be affected; when suffering from depression and other mental illnesses, may also appear chest tightness, sleep disorders and other clinical symptoms. It is recommended that people with chest tightness who feel blocked by something go to a regular hospital in time to clarify the cause, and if treatment is needed, it should be standardized under the guidance of a doctor.