Clinical toothache is often treated with ibuprofen and ceftriaxone combined with metronidazole for pain relief and anti-inflammation. Ibuprofen can effectively relieve all types of pain, and ceftriaxone combined with metronidazole can effectively eliminate periodontal inflammation. Toothache is caused by bacterial infection of the tooth, and antibiotics can control the bacterial infection and thus stop the pain. Commonly used drugs can be divided into the following categories: a. Pain relief: pain relief often chosen drugs are non-steroidal anti-inflammatory drugs, such as ibuprofen, aspirin, paracetamol, etc., is also the most commonly used clinical painkillers, clear efficacy, and will not have addictive, for various causes of pain, toothache generally use such drugs to stop pain fast. Second, anti-inflammatory: 1, nitroimidazoles: toothache anti-inflammatory generally preferred nitroimidazoles, common metronidazole, tinidazole, ornidazole, etc., because metronidazole is cheaper and more effective, so the clinical toothache often use this drug; 2, cephalosporins: such as ceftriaxone, cefuroxime, cefixime, etc.; 3, tetracyclines: there are also tetracyclines, including tetracycline, doxycycline, etc., but easy to cause tooth coloring; 4, penicillins: commonly used amoxicillin, and combined with metronidazole can enhance the efficacy of periodontitis, but be wary of penicillin allergy situation. In addition, even if the symptoms of toothache are relieved after taking medicine, the causes of toothache still exist, such as tooth decay, tooth fracture, pulpitis, periodontitis and so on. You should still go to the dental clinic for consultation and treatment in time. In addition some maxillofacial diseases such as maxillofacial infection and inflammation, nerve pain such as trigeminal neuralgia and other causes can also cause periapical pain and should be identified.