Recently, we admitted a female patient with “toothache to be investigated” to our cardiology department, and you must be wondering why the cardiology ward would admit a patient with a toothache that is not related to any other. Here’s the story, let me tell it in detail …… The patient had lower toothache with chest tightness and palpitations at night for about 2 hours with no apparent cause a month ago, which resolved on its own without special treatment; recently, the above symptoms worsened and were occasionally accompanied by headache, and when the symptoms recurred at night, she went to our emergency clinic and had her blood pressure measured at 186/113 The blood pressure was measured at 186/113 mmHg, and the electrocardiogram showed sinus tachycardia; possible infarction in the lower wall (arrows, pathological Q waves in leads III and avF). After admission to our department, medication was given and coronary angiography was performed after perfecting the preoperative preparation. Intraoperative indications were: diffuse mild stenosis in the proximal, middle and distal segments of the LAD, moderate stenosis in the D1 opening and middle segment; mild stenosis in the proximal segment of the LCX; mild stenosis in the distal segment of the RCA. In this way, do you still think that toothache and heart disease are not related to each other? In fact, during an angina attack or some other heart disease, the pain can often radiate to the left side of the jaw or left side of the teeth, resulting in the so-called alveolar pain or lower tooth pain. It is worth noting that the toothache caused by angina pectoris in coronary heart disease is often dominated by pain on one side of the toothbed, mostly on the left side, compared to the general toothache, and it is often difficult to determine exactly which tooth is in pain, and it is not accompanied by gum, cheek redness, swelling and fever. If there is no abnormality after oral examination, but the patient has cardiovascular disease risk factors such as hypertension, hyperlipidemia, diabetes, and heavy smoking and drinking, we should consider that the toothache may be caused by myocardial ischemia of coronary heart disease. In particular, if toothache occurs frequently during exertion and emotional stress, you should be alert to myocardial ischemia in coronary artery disease, and you should visit the cardiology department in time to get a clear diagnosis through coronary CTA or coronary angiography. Toothache is easily ignored in real life. Patients with toothache often visit the dentistry department first, and after no obvious abnormality is seen in the oral examination, they may often neglect the follow-up examination, which may delay the diagnosis and treatment of potential heart disease and cause some harm. Therefore, when you have a history of coronary heart disease or other cardiovascular risk factors, do not ignore the cardiogenic factors when toothache occurs, and it is recommended to visit the cardiology department in time.