Itchy armpits with hard bumps may be folliculitis, eczema, soft fibroma and other diseases, patients need to follow the doctor’s instructions for medication, general measures, physical therapy, and so on, and if necessary, also need to carry out surgical treatment. 1. Folliculitis: Usually patients need to follow the doctor’s instructions to use chlorhexidine gluconate solution, povidone-iodine solution and other antibacterial lotion treatment. Can also be used with topical mupirocin ointment, fusidic acid ointment and other antibiotic medication. If the patient’s condition is more severe and a bacterial infection is present, oral antibiotic medications such as cefuroxime and doxycycline are also required. If the folliculitis develops into boils, surgery is needed to cut and drain. 2. Eczema: Usually, if there are no blisters, vesicles, or oozing, patients can follow the doctor’s instructions to use topical glycerin lotion and mometasone furoate ointment. If there is oozing, it is also necessary to use 3% boric acid solution, 0.1% ethacridine solution and so on. Topical zinc oxide oil can also be used if there is erosion but less exudation. Some patients can also systematically use calcium gluconate, vitamin C and other medications. 3. Soft fibroma: usually patients need to follow the doctor’s instructions for laser treatment, for patients with tips can be directly cut off the skin, through the mild electric drying method for hemostasis. Patients can also be matched with physical therapy such as electrocautery and liquid nitrogen freezing. If the tumor is large, surgical ligation or excision is also required. It is recommended that patients with itchy hard bumps in the armpits take reasonable treatment measures according to the cause as prescribed by the doctor.