At present, the situation of antibiotic resistance is becoming more and more common, and no matter what method is used, it is certain that the rational application of antibiotics is the fundamental way to solve the problem of drug resistance. At present, scientists in various countries are actively researching the mechanism of microbial resistance generation, and the strategies and experiences of some countries in controlling the misuse of antibiotics also have some reference effect on us. First, a standardized management system and system should be established for the use of antibiotics by physicians. Duan Shaobin, Department of Surgery, Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine, U.S. Center for Disease Management, introduced countermeasures from the autumn of 1997 to reduce the misuse of antibiotics, including what kind of diseases can use antibiotics, how doctors can instruct patients in detail about the use of drugs, and also compiled guidelines for the use of antibiotics, etc. Second, a strict system of differentiation and management between prescription and over-the-counter drugs was implemented for the use and sale of antibiotics, with prescription drugs having to be purchased with a doctor’s prescription and applied under the guidance of medical staff. Third, the establishment of a large team of professional pharmacists for the strict supervision of prescription drugs, prescription drugs can not be bought in pharmacies or drugstores, patients must be examined by a clinician and prescribed, and then go to a pharmacy or drugstore to get the prescription drugs after examination by a licensed pharmacist. Another function of the licensed pharmacist is to guide patients in the rational use of drugs, so that pharmacists come from behind the scenes to the front stage and teach patients face to face the correct use of prescription drugs, in order to ensure the rational application of various prescription drugs, so as to prevent the maximum abuse of antibiotics. Fourth, ban or restrict the use of antibiotics in animals and plants. The European Commission currently proposes to ban the use of antibiotics as feed growth additives, and has approved four categories of antibiotics as feed additives will be phased out of the market by January 2006.