High bilirubin, that is, total bilirubin, direct bilirubin and indirect bilirubin are all significantly increased, most of them are considered to be liver lesions, which need to be treated according to the specific cause of the disease, including antiviral drugs, hepatoprotective and enzyme-lowering medications, and medications to improve the metabolism of bilirubin. Viral hepatitis, drug hepatitis, alcoholic hepatitis and other diseases, because the patient accompanied by liver function damage, need to use liver-protecting and enzyme-lowering drugs, such as silymarin capsule, compound glycyrrhizin tablets, compound glutathione, etc.; the use of drugs to improve the metabolism of bilirubin, such as arbutin deoxycholic acid, adenosylmethionine and so on. For viral hepatitis, antiviral therapy should also be used. Hepatitis B patients can choose entecavir, tenofovir, etc. Hepatitis C patients can choose sofosbuvir, combined with pegylated interferon-alpha or ribavirin, etc. for treatment. Specific medication needs to follow the doctor’s prescription, not unauthorized medication. During active treatment, patients with drug hepatitis must stop the use of drugs that harm the liver, and patients with alcoholic hepatitis must strictly abstain from alcohol and eat a light, low-fat diet. Drugs need to be used under the guidance of a professional physician, not unauthorized use of drugs.