Cardiac neurosis does not have organic heart changes; patients with coronary artery disease are experiencing severe narrowing of the coronary arteries. Cardiac neurosis belongs to the psychological aspect of the disease, although the patient has chest pain, chest tightness and other symptoms, but there is no organic heart changes; patients with coronary heart disease secondary to coronary atherosclerosis, there is a serious stenosis in the coronary arteries, resulting in patients with myocardial ischemic episodes, belonging to the organic heart disease. The treatment of patients with cardiac neurosis is based on anti-anxiety and anti-depression, psychological counseling when necessary, oral sedative medication, such as alprazolam. Patients with coronary artery disease should take oral aspirin atorvastatin and other drugs, patients with angina need to take oral isosorbide nitrate, and serious conditions require implantation of stents. Cardiac neurosis and coronary heart disease treatment methods are completely different, there are symptoms of the physician under the guidance of a clear diagnosis, choose a targeted treatment.