For advanced lung cancer, especially locally advanced stage III non-small cell lung cancer, synchronized chemoradiotherapy is an important treatment strategy and tool if eligible, reflecting the basic principles of multidisciplinary and comprehensive tumor treatment; for advanced stage IV patients with distant metastases, synchronized palliative chemoradiotherapy can also benefit patients clinically. However, as with other treatments, there are pros and cons, and physicians, patients and families need to weigh the pros and cons and make a calm and rational choice, rather than a uniform synchronization. First of all, in terms of benefit, the near and long-term efficacy of synchronized chemoradiotherapy is definitely the best, and patients will benefit the most clinically, which can not only enable the rapid removal of peripheral circulating cancer cells and occult micrometastases, but also enable the rapid reduction of local primary lesions, thus relieving local compression and local invasive symptoms and improving patients’ quality of life. Therefore, for those who are expected to tolerate the treatment, they can be boldly tried to obtain the best efficacy. Secondly, while emphasizing the advantages of synchronized radiotherapy, as a doctor, we should also inform patients and their families of its disadvantages, i.e., the so-called “physical” side, especially because the Chinese physique is less tolerant and less compliant with synchronized radiotherapy than the Westerners, and many patients cannot understand the common side effects of radiotherapy and cannot complete the expected treatment. Many patients are unable to complete the expected treatment due to the common side effects of radiotherapy, which is not worth the loss. For example, difficulty in eating due to radiation esophagitis, cough and breathing difficulty due to radiation pneumonia, abnormal cognitive behavior due to local palliative radiotherapy for brain metastases, ……, etc. All these, as doctors, should be informed in detail, as patients and family members, should be prepared in advance for the occurrence of these complications, otherwise, once occur, there is no going back. In fact, if you are really fearful of simultaneous radiotherapy and chemotherapy, you have to take the second best option and use sequential radiotherapy, that is, chemotherapy first and then radiotherapy after completing the necessary course of treatment, which is a better choice for the national physique.