Elevated C-reactive protein is a non-specific indicator and can be seen in a variety of pathological conditions. It is not possible to specify the exact time of decline to normal and should be analyzed on a problem-specific basis. C-reactive protein can be seen in stress, infection and other disease states, and is often a sensitive indicator of the acute phase of a lesion, and the time to decrease C-reactive protein varies from disease to disease. For example, in general septic infections, the C-reactive protein can decrease accordingly after the inflammation is controlled in about 5-10 days. For larger surgeries, C-reactive protein may increase within 6 hours and may decrease to normal levels within 2-10 days if there are no other complications. In patients with myocardial infarction, C-reactive protein can decrease to normal in about 3-5 days if coronary stenting is performed. As for malignant tumors and connective tissue, there is no specific time for C-reactive protein to drop and repeated rises may occur during the course of disease treatment. In conclusion, C-reactive protein can be used as a detection indicator of disease regression, and only plays an auxiliary role; patients should pay more attention to the treatment of the primary disease.