Minor triple positive with splenomegaly is a diagnosis of imaging examination combined with laboratory tests. Minor triple positive refers to a manifestation that the body is positive for Hepatitis B surface antigen, Hepatitis B E antibody and core antibody, which belongs to the stable state of the virus in the body. Slightly enlarged spleen refers to the abdominal ultrasound examination, which reveals that the spleen volume exceeds the normal range. At this time, it is necessary to judge the liver damage to make a comprehensive diagnosis. 1. There is not necessarily a correlation between small triple positive status and a slightly enlarged spleen. If there is no obvious damage to the liver and the portal vein pressure is normal, it suggests that the spleen may be simply slightly enlarged, which may be caused by congenital development, and there is no need to intervene too much. 2. In some cases of minor triple positive, the patient’s liver is sclerotic and the portal vein pressure increases, which indirectly causes the spleen to enlarge, suggesting that the liver condition is abnormal and affects the spleen, and it is necessary to combine with other indexes to make a comprehensive judgment, which mainly includes the liver function and the coagulation function condition, etc., and carry out the treatment under the guidance of the clinician. It is also necessary to combine with liver function tests, portal vein pressure measurement and other comprehensive judgment, after the discovery of abnormalities under the guidance of clinicians for standardized treatment.