Prolonged chest tightness and breath-holding, should improve the examination, may need to be given in conjunction with the cause of the anti-infection, bronchodilatation, cardiotonic, diuretic, correct anemia treatment. Bronchial asthma, chronic obstructive pulmonary disease, interstitial pneumonia can cause long-term chest tightness and breathlessness. Chest CT examination is needed, and anti-infection treatment, inhalation of salbutamol and budesonide to calm asthma and dilate bronchial tubes are needed when coughing up more sputum. Poor lung function requires home oxygen therapy and ventilator-assisted breathing. With hypertensive cardiomyopathy, coronary artery disease, heart valve disease, arrhythmia, heart failure when the performance of chest tightness and shortness of breath, should improve the electrocardiogram, coronary arteriography, cardiac ultrasound examination, B-type brain natriuretic peptide precursor. Active treatment of the primary disease, nifedipine antihypertensive, aspirin anti-platelet, atorvastatin lipid regulation, antiarrhythmic therapy. Heart failure requires the addition of furosemide, spironolactone diuretics to reduce cardiac load. Anemia can cause chest tightness and breathlessness, improve the routine blood test, if necessary, improve gastroscopy, enteroscopy, anemia three, anemia screening, rheumatism and immunity test, bone marrow examination, to clarify the cause of anemia. Correct anemia according to the cause of treatment, severe anemia needs blood transfusion treatment. Prolonged chest tightness and breathlessness, should go to the hospital to improve the examination, clear diagnosis, according to the doctor’s prescription medication.