5-hydroxytryptamine receptors play a key role in the central control of ejaculation, paroxetine hydrochloride belongs to the class of 5-hydroxytryptamine reuptake blockers, which can block the reabsorption of 5-hydroxytryptamine, enhance the action of 5-hydroxytryptamine, increase the ejaculation threshold, thus prolonging the ejaculation latency time of patients with premature ejaculation, so as to achieve the purpose of treating premature ejaculation. Paroxetine hydrochloride is contraindicated for allergic people, and may cause adverse reactions such as weakness, constipation, diarrhea, headache, insomnia, anxiety, palpitations, etc. after taking paroxetine hydrochloride. Premature ejaculation is also associated with psychological factors, circumcision and prostatitis and other factors, can not completely rely on paroxetine hydrochloride to treat premature ejaculation, should actively search for the cause of the disease, according to the cause of the treatment of the disease may be completely improved. Premature ejaculation patients should go to the hospital in a timely manner, under the guidance of the doctor standardized treatment, avoid home self-medication.