The high-risk groups for hepatitis B infection are as follows: 1, mainly including medical personnel, those who have frequent contact with blood products, frequent blood transfusions, had organ transplants, and those who are immunocompromised (long-term immunosuppressive drugs); 2, those whose family members have hepatitis B infection and whose family members are also at high risk; 3, those who are engaged in the catering industry, early childhood education or other educational workers; 4, those who are negative for hepatitis B protective antibodies. It should be pointed out that there are no special symptoms in the early stage of hepatitis B infection, so it is not accurate to rely on symptoms for screening, and serological markers for hepatitis B should be done regularly.