The interbrow is a smooth, flat, triangular area located just above the base of the nose. Muscle contractions in the brow (four groups of descending muscles) result in horizontal and vertical wrinkles. These muscles assist in protecting the eyes from dust, sand, and particles by lowering and inwardly retracting the brow. However, when these descending muscles move excessively to produce a persistent, unconscious inward contraction and lowering of the brow, it can lead to frown lines between the brows. By weakening the contraction of these four groups of descending muscles through Botox injections, the effect of lifting the brow and reducing wrinkles can be achieved, making a person appear to have a more relaxed expression. It is important to note, however, that not everyone’s frown lines between the brows can be removed with Botox injections. If the patient has thin subcutaneous fat between the eyebrows and shallow wrinkles, the wrinkles can be easily reduced or disappeared by finger stretching, then the application of Botox injections can achieve good and long-lasting results; if the patient has thick subcutaneous fat and deep wrinkles, it is difficult to spread the wrinkles with fingers, then the response to Botox treatment is poor, and this type of patient is commonly seen in men or women who work outdoors for a long time. There is also a group of patients with deep wrinkles that can be easily spread out, but the skin lacks elasticity and has obvious sagging, which is common in older patients. The effect of botulinum toxin injections for the treatment of frown lines between the eyebrows generally lasts for 3 to 4 months, and in some patients for 6 to 8 months. Patients may experience bilateral asymmetry after the first injection and therefore need to be given a second treatment 2 to 3 weeks after the injection. Supplemental treatment can make the botulinum toxin work for a longer period of time. Local edema, petechiae, rash, headache, and flu-like symptoms may occur after the injection and generally do not require treatment; these symptoms will disappear after 1 day of treatment. Ptosis is the most common complication following botulinum toxin injections in the interbrow area. It is mainly due to the dissemination of botulinum toxin to the levator muscle after injection, weakening its function to lift the upper eyelid. It often occurs in patients with greater dilution and deeper or lower injections. Another potential complication of incomplete eyelid closure is the inability to fully close the upper and lower eyelids due to a weakened sphincter of the orbicularis oculi muscle. Failure to close the eyelids can lead to corneal exophthalmos, dry eye, or exposure keratitis. When these complications occur, it is important to seek help from a professional plastic surgeon at a specialized medical facility. In recent years, in addition to the application of botulinum toxin injections to correct the wrinkles between the eyebrows, buried wire filling of the wrinkles between the eyebrows has received more and more favorable treatment with the characteristics of less trauma, short operation time, significant effect and long duration. The procedure involves the direct filling of frown lines in the area between the eyebrows with 10-20 wires buried in a parallel or net-like cross arrangement.